Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.

Lahti, J.; Tuominen, S.; Yang, Q.; Pergola, G.; Ahmad, S.; Amin, N.; Armstrong, N.J.; Beiser, A.; Bey, K.; Bis, J.C.; Boerwinkle, E.; Bressler, J.; Campbell, A.; Campbell, H.; Chen, Q.; Corley, J.; Cox, S.R.; Davies, G.; De Jager, P.L.; Derks, E.M.; Faul, J.D.; Fitzpatrick, A.L.; Fohner, A.E.; Ford, I.; Fornage, M.; Gerring, Z.; Grabe, H.J.; Grodstein, F.; Gudnason, V.; Simonsick, E.; Holliday, E.G.; Joshi, P.K.; Kajantie, E.; Kaprio, J.; Karell, P.; Kleineidam, L.; Knol, M.J.; Kochan, N.A.; Kwok, J.B.; Leber, M.; Lam, M.; Lee, T.; Li, S.; Loukola, A.; Luck, T.; Marioni, R.E.; Mather, K.A.; Medland, S.; Mirza, S.S.; Nalls, M.A.; Nho, K.; O'Donnell, A.; Oldmeadow, C.; Painter, J.; Pattie, A.; Reppermund, S.; Risacher, S.L.; Rose, R.J.; Sadashivaiah, V.; Scholz, M.; Satizabal, C.L.; Schofield, P.W.; Schraut, K.E.; Scott, R.J.; Simino, J.; Smith, A.V.; Smith, J.A.; Stott, D.J.; Surakka, I.; Teumer, A.; Thalamuthu, A.; Trompet, S.; Turner, S.T.; van der Lee, S.J.; Villringer, A.; Völker, U.; Wilson, R.S.; Wittfeld, K.; Vuoksimaa, E.; Xia, R.; Yaffe, K.; Yu, L.; Zare, H.; Zhao, W.; Ames, D.; Attia, J.; Bennett, D.A.; Brodaty, H.; Chasman, D.I.; Goldman, A.L.; Hayward, C.; Ikram, M.A.; Jukema, J.W.; Kardia, SLR; Lencz, T.; Loeffler, M.; Mattay, V.S.; Palotie, A.; Psaty, B.M.; Ramirez, A.; Ridker, P.M.; Riedel-Heller, S.G.; Sachdev, P.S.; Saykin, A.J.; Scherer, M.; Schofield, P.R.; Sidney, S.; Starr, J.M.; Trollor, J.; Ulrich, W.; Wagner, M.; Weir, D.R.; Wilson, J.F.; Wright, M.J.; Weinberger, D.R.; Debette, S.; Eriksson, J.G.; Mosley, T.H.; Launer, L.J.; van Duijn, C.M.; Deary, I.J.; Seshadri, S.; Räikkönen, K.

doi:10.1038/s41380-022-01710-8

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.

Détails

Télécharger: 35974141_BIB_594899019EA4.pdf (3555.96 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0

ID Serval

serval:BIB_594899019EA4

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.

Périodique

Molecular psychiatry

Auteur⸱e⸱s

Lahti J., Tuominen S., Yang Q., Pergola G., Ahmad S., Amin N., Armstrong N.J., Beiser A., Bey K., Bis J.C., Boerwinkle E., Bressler J., Campbell A., Campbell H., Chen Q., Corley J., Cox S.R., Davies G., De Jager P.L., Derks E.M., Faul J.D., Fitzpatrick A.L., Fohner A.E., Ford I., Fornage M., Gerring Z., Grabe H.J., Grodstein F., Gudnason V., Simonsick E., Holliday E.G., Joshi P.K., Kajantie E., Kaprio J., Karell P., Kleineidam L., Knol M.J., Kochan N.A., Kwok J.B., Leber M., Lam M., Lee T., Li S., Loukola A., Luck T., Marioni R.E., Mather K.A., Medland S., Mirza S.S., Nalls M.A., Nho K., O'Donnell A., Oldmeadow C., Painter J., Pattie A., Reppermund S., Risacher S.L., Rose R.J., Sadashivaiah V., Scholz M., Satizabal C.L., Schofield P.W., Schraut K.E., Scott R.J., Simino J., Smith A.V., Smith J.A., Stott D.J., Surakka I., Teumer A., Thalamuthu A., Trompet S., Turner S.T., van der Lee S.J., Villringer A., Völker U., Wilson R.S., Wittfeld K., Vuoksimaa E., Xia R., Yaffe K., Yu L., Zare H., Zhao W., Ames D., Attia J., Bennett D.A., Brodaty H., Chasman D.I., Goldman A.L., Hayward C., Ikram M.A., Jukema J.W., Kardia SLR, Lencz T., Loeffler M., Mattay V.S., Palotie A., Psaty B.M., Ramirez A., Ridker P.M., Riedel-Heller S.G., Sachdev P.S., Saykin A.J., Scherer M., Schofield P.R., Sidney S., Starr J.M., Trollor J., Ulrich W., Wagner M., Weir D.R., Wilson J.F., Wright M.J., Weinberger D.R., Debette S., Eriksson J.G., Mosley T.H., Launer L.J., van Duijn C.M., Deary I.J., Seshadri S., Räikkönen K.

ISSN

1476-5578 (Electronic)

ISSN-L

1359-4184

Statut éditorial

Publié

Date de publication

11/2022

Peer-reviewed

Oui

Volume

Numéro

Pages

4419-4431

Langue

anglais

Notes

Publication types: Journal Article
Publication Status: ppublish

Résumé

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Mots-clé

Memory, Short-Term/physiology, Learning, Verbal Learning, Multifactorial Inheritance, Brain

URN

urn:nbn:ch:serval-BIB_594899019EA41

OAI-PMH

oai:serval.unil.ch:BIB_594899019EA4

DOI

10.1038/s41380-022-01710-8

Pubmed

35974141

Web of science

000841124300001