Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_594899019EA4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Journal
Molecular psychiatry
Author(s)
Lahti J., Tuominen S., Yang Q., Pergola G., Ahmad S., Amin N., Armstrong N.J., Beiser A., Bey K., Bis J.C., Boerwinkle E., Bressler J., Campbell A., Campbell H., Chen Q., Corley J., Cox S.R., Davies G., De Jager P.L., Derks E.M., Faul J.D., Fitzpatrick A.L., Fohner A.E., Ford I., Fornage M., Gerring Z., Grabe H.J., Grodstein F., Gudnason V., Simonsick E., Holliday E.G., Joshi P.K., Kajantie E., Kaprio J., Karell P., Kleineidam L., Knol M.J., Kochan N.A., Kwok J.B., Leber M., Lam M., Lee T., Li S., Loukola A., Luck T., Marioni R.E., Mather K.A., Medland S., Mirza S.S., Nalls M.A., Nho K., O'Donnell A., Oldmeadow C., Painter J., Pattie A., Reppermund S., Risacher S.L., Rose R.J., Sadashivaiah V., Scholz M., Satizabal C.L., Schofield P.W., Schraut K.E., Scott R.J., Simino J., Smith A.V., Smith J.A., Stott D.J., Surakka I., Teumer A., Thalamuthu A., Trompet S., Turner S.T., van der Lee S.J., Villringer A., Völker U., Wilson R.S., Wittfeld K., Vuoksimaa E., Xia R., Yaffe K., Yu L., Zare H., Zhao W., Ames D., Attia J., Bennett D.A., Brodaty H., Chasman D.I., Goldman A.L., Hayward C., Ikram M.A., Jukema J.W., Kardia SLR, Lencz T., Loeffler M., Mattay V.S., Palotie A., Psaty B.M., Ramirez A., Ridker P.M., Riedel-Heller S.G., Sachdev P.S., Saykin A.J., Scherer M., Schofield P.R., Sidney S., Starr J.M., Trollor J., Ulrich W., Wagner M., Weir D.R., Wilson J.F., Wright M.J., Weinberger D.R., Debette S., Eriksson J.G., Mosley T.H., Launer L.J., van Duijn C.M., Deary I.J., Seshadri S., Räikkönen K.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
Published
Issued date
11/2022
Peer-reviewed
Oui
Volume
27
Number
11
Pages
4419-4431
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Keywords
Memory, Short-Term/physiology, Learning, Verbal Learning, Multifactorial Inheritance, Brain
Pubmed
Web of science
Open Access
Yes
Create date
10/07/2023 14:05
Last modification date
23/01/2024 8:26
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