Lentiviral-mediated gene transfer of siRNAs for the treatment of Huntington's disease.

Détails

ID Serval
serval:BIB_5873B39F3C1D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lentiviral-mediated gene transfer of siRNAs for the treatment of Huntington's disease.
Périodique
Methods in Molecular Biology
Auteur(s)
Cambon K., Déglon N.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2013
Volume
1010
Pages
95-109
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
This chapter describes the potential use of viral-mediated gene transfer in the central nervous system for the silencing of gene expression using RNA interference in the context of Huntington's disease (HD). Protocols provided here describe the design of small interfering RNAs, their encoding in lentiviral vectors (LVs) and viral production, as well as procedures for their stereotaxic injection in the rodent brain.
Pubmed
Création de la notice
13/12/2011 18:23
Dernière modification de la notice
20/08/2019 15:12
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