Asymmetrical localization of benzodiazepine receptors in the human auditory cortex

Détails

ID Serval
serval:BIB_580A6A0F59B0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Asymmetrical localization of benzodiazepine receptors in the human auditory cortex
Périodique
Acta Otolaryngol
Auteur(s)
Morand N., Bouvard S., Ryvlin P., Mauguiere F., Fischer C., Collet L., Veuillet E.
ISSN
0001-6489 (Print)
ISSN-L
0001-6489
Statut éditorial
Publié
Date de publication
01/2001
Volume
121
Numéro
2
Pages
293-6
Langue
anglais
Notes
Morand, N
Bouvard, S
Ryvlin, P
Mauguiere, F
Fischer, C
Collet, L
Veuillet, E
eng
England
Acta Otolaryngol. 2001 Jan;121(2):293-6.
Résumé
In humans, administration of benzodiazepines (BZD) has been shown to have an asymmetrical effect on the medial olivocochlear system. Indeed, a decrease of evoked otoacoustic emission suppression by contralateral acoustic stimulation, which explores the medial olivocochlear efferent system, was observed in the right ear, with no left ear effect. This result suggests a possible left-right auditory pathway BZD receptor asymmetry. Given the anatomical link between auditory centers and the medial olivocochlear system, the existence of a larger volume of cortical connecting fibers in the left hemisphere, and the possible link between BZD receptor density and neuronal density, we tested the hypothesis of an asymmetrical localization of BZD receptors in the auditory system in 10 right-handed subjects using [11C]flumazenil positron emission tomography. Semi-quantitative measurements of flumazenil binding were evaluated in Heschl's gyrus showing a left-right asymmetry in favor of left auditory cortex. This result indicates a higher density of neurons in left auditory cortex. The possible link between neurochemical asymmetry and functional asymmetry, and the perceptual outcome of BZD administration, will be discussed.
Mots-clé
Adult, Auditory Cortex/*diagnostic imaging, Auditory Pathways/*diagnostic imaging, Brain Mapping, Cochlear Nucleus/diagnostic imaging, Dominance, Cerebral/*physiology, Humans, Male, Olivary Nucleus/diagnostic imaging, Receptors, GABA-A/*analysis, Reference Values, Tomography, Emission-Computed
Pubmed
Création de la notice
29/11/2018 13:37
Dernière modification de la notice
20/08/2019 15:11
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