Asymmetrical localization of benzodiazepine receptors in the human auditory cortex

Details

Serval ID
serval:BIB_580A6A0F59B0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Asymmetrical localization of benzodiazepine receptors in the human auditory cortex
Journal
Acta Otolaryngol
Author(s)
Morand N., Bouvard S., Ryvlin P., Mauguiere F., Fischer C., Collet L., Veuillet E.
ISSN
0001-6489 (Print)
ISSN-L
0001-6489
Publication state
Published
Issued date
01/2001
Volume
121
Number
2
Pages
293-6
Language
english
Notes
Morand, N
Bouvard, S
Ryvlin, P
Mauguiere, F
Fischer, C
Collet, L
Veuillet, E
eng
England
Acta Otolaryngol. 2001 Jan;121(2):293-6.
Abstract
In humans, administration of benzodiazepines (BZD) has been shown to have an asymmetrical effect on the medial olivocochlear system. Indeed, a decrease of evoked otoacoustic emission suppression by contralateral acoustic stimulation, which explores the medial olivocochlear efferent system, was observed in the right ear, with no left ear effect. This result suggests a possible left-right auditory pathway BZD receptor asymmetry. Given the anatomical link between auditory centers and the medial olivocochlear system, the existence of a larger volume of cortical connecting fibers in the left hemisphere, and the possible link between BZD receptor density and neuronal density, we tested the hypothesis of an asymmetrical localization of BZD receptors in the auditory system in 10 right-handed subjects using [11C]flumazenil positron emission tomography. Semi-quantitative measurements of flumazenil binding were evaluated in Heschl's gyrus showing a left-right asymmetry in favor of left auditory cortex. This result indicates a higher density of neurons in left auditory cortex. The possible link between neurochemical asymmetry and functional asymmetry, and the perceptual outcome of BZD administration, will be discussed.
Keywords
Adult, Auditory Cortex/*diagnostic imaging, Auditory Pathways/*diagnostic imaging, Brain Mapping, Cochlear Nucleus/diagnostic imaging, Dominance, Cerebral/*physiology, Humans, Male, Olivary Nucleus/diagnostic imaging, Receptors, GABA-A/*analysis, Reference Values, Tomography, Emission-Computed
Pubmed
Create date
29/11/2018 12:37
Last modification date
20/08/2019 14:11
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