Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis.

Détails

ID Serval
serval:BIB_57E6387B5509
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis.
Périodique
Forensic science international
Auteur⸱e⸱s
Garland J., Ondruschka B., Da Broi U., Palmiere C., Tse R.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Statut éditorial
Publié
Date de publication
09/2020
Peer-reviewed
Oui
Volume
314
Pages
110415
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.
Mots-clé
Anaphylaxis/diagnosis, Artifacts, Asthma/blood, Biomarkers/blood, Cardiovascular Diseases/blood, Drug Overdose/blood, Forensic Medicine, Hemolysis, Humans, Infant, Newborn, Inflammation/blood, Kounis Syndrome/blood, Mastocytosis/complications, Postmortem Changes, Reference Values, Resuscitation, Specimen Handling, Sudden Infant Death/blood, Tryptases/blood, Wounds and Injuries/blood, Anaphylaxis, Post mortem biochemistry, Post mortem tryptase, Tryptase
Pubmed
Web of science
Création de la notice
28/07/2020 14:47
Dernière modification de la notice
04/03/2021 6:26
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