Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis.

Details

Serval ID
serval:BIB_57E6387B5509
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis.
Journal
Forensic science international
Author(s)
Garland J., Ondruschka B., Da Broi U., Palmiere C., Tse R.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
314
Pages
110415
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.
Keywords
Anaphylaxis, Post mortem biochemistry, Post mortem tryptase, Tryptase
Pubmed
Web of science
Create date
28/07/2020 14:47
Last modification date
04/02/2021 6:25
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