Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.

Détails

ID Serval
serval:BIB_579D7E90276B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.
Périodique
American Journal of Clinical Nutrition
Auteur⸱e⸱s
Theytaz F., Noguchi Y., Egli L., Campos V., Buehler T., Hodson L., Patterson B.W., Nishikata N., Kreis R., Mittendorfer B., Fielding B., Boesch C., Tappy L.
ISSN
1938-3207 (Electronic)
ISSN-L
0002-9165
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
96
Numéro
5
Pages
1008-1016
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND: A high dietary protein intake has been shown to blunt the deposition of intrahepatic lipids in high-fat- and high-carbohydrate-fed rodents and humans.
OBJECTIVE: The aim of this study was to evaluate the effect of essential amino acid supplementation on the increase in hepatic fat content induced by a high-fructose diet in healthy subjects.
DESIGN: Nine healthy male volunteers were studied on 3 occasions in a randomized, crossover design after 6 d of dietary intervention. Dietary conditions consisted of a weight-maintenance balanced diet (control) or the same balanced diet supplemented with 3 g fructose · kg(-1) · d(-1) and 6.77 g of a mixture of 5 essential amino acids 3 times/d (leucine, isoleucine, valine, lysine, and threonine) (HFrAA) or with 3 g fructose · kg(-1) · d(-1) and a maltodextrin placebo 3 times/d (HFr); there was a washout period of 4 to 10 wk between each condition. For each condition, the intrahepatocellular lipid (IHCL) concentration, VLDL-triglyceride concentration, and VLDL-[(13)C]palmitate production were measured after oral loading with [(13)C]fructose.
RESULTS: HFr increased the IHCL content (1.27 ± 0.31 compared with 2.74 ± 0.55 vol %; P < 0.05) and VLDL-triglyceride (0.55 ± 0.06 compared with 1.40 ± 0.15 mmol/L; P < 0.05). HFr also enhanced VLDL-[(13)C]palmitate production. HFrAA significantly decreased IHCL compared with HFr (to 2.30 ± 0.43 vol%; P < 0.05) but did not change VLDL-triglyceride concentrations or VLDL-[(13)C]palmitate production.
CONCLUSIONS: Supplementation with essential amino acids blunts the fructose-induced increase in IHCL but not hypertriglyceridemia. This is not because of inhibition of VLDL-[(13)C]palmitate production. This trial was registered at www.clinicaltrials.gov as NCT01119989.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/11/2012 22:23
Dernière modification de la notice
20/08/2019 15:11
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