AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.

Détails

Ressource 1Télécharger: 18951085_Postprint.pdf (4402.75 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_5758E4C87E3C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
Périodique
Molecular Cell
Auteur⸱e⸱s
Carnegie G.K., Soughayer J., Smith F.D., Pedroja B.S., Zhang F., Diviani D., Bristow M.R., Kunkel M.T., Newton A.C., Langeberg L.K., Scott J.D.
ISSN
1097-4164 ([electronic])
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
32
Numéro
2
Pages
169-179
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy. We have discovered that the A-Kinase Anchoring Protein (AKAP)-Lbc is upregulated in hypertrophic cardiomyocytes. It coordinates activation and movement of signaling proteins that initiate MEF2-mediated transcriptional reprogramming events. Live-cell imaging, fluorescent kinase activity reporters, and RNA interference techniques show that AKAP-Lbc couples activation of protein kinase D (PKD) with the phosphorylation-dependent nuclear export of the class II histone deacetylase HDAC5. These studies uncover a role for AKAP-Lbc in which increased expression of the anchoring protein selectively amplifies a signaling pathway that drives cardiac myocytes toward a pathophysiological outcome.
Mots-clé
14-3-3 Proteins/metabolism, A Kinase Anchor Proteins/genetics, A Kinase Anchor Proteins/metabolism, Active Transport, Cell Nucleus, Animals, COS Cells, Cardiomegaly/metabolism, Cell Line, Cercopithecus aethiops, Cyclic AMP-Dependent Protein Kinases/metabolism, Gene Expression Regulation, Guanine Nucleotide Exchange Factors/genetics, Guanine Nucleotide Exchange Factors/metabolism, Heart Ventricles/drug effects, Histone Deacetylases/metabolism, Humans, Models, Biological, Myocytes, Cardiac/drug effects, Myocytes, Cardiac/metabolism, Myogenic Regulatory Factors/metabolism, Phenylephrine/pharmacology, Phosphorylation, Protein Kinase C/metabolism, Proto-Oncogene Proteins/genetics, Proto-Oncogene Proteins/metabolism, RNA Interference, Rats, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/12/2008 17:25
Dernière modification de la notice
23/11/2020 12:06
Données d'usage