Intravaginal live attenuated Salmonella increase local antitumor vaccine-specific CD8(+) T cells.
Détails
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_5658EE1F539B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intravaginal live attenuated Salmonella increase local antitumor vaccine-specific CD8(+) T cells.
Périodique
Oncoimmunology
ISSN
2162-4011 (Print)
Statut éditorial
Publié
Date de publication
2013
Volume
2
Numéro
1
Pages
e22944
Langue
anglais
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish. PDF type: Brief report
Résumé
We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8(+) T cells in the genital mucosa of mice, without affecting E7-specific systemic responses. Here, we show that the instillation of live attenuated Salmonella enterica serovar Typhimurium similarly, though more efficiently (~15- fold), increases both E7-specific and total CD8(+) T cells in the genital mucosa. Cancer immunotherapeutic strategies combining vaccination with local immunostimulation with live bacteria deserve further investigations.
Pubmed
Web of science
Création de la notice
09/05/2013 14:59
Dernière modification de la notice
21/11/2022 9:30