Intravaginal live attenuated Salmonella increase local antitumor vaccine-specific CD8(+) T cells.

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Version: Final published version
Serval ID
serval:BIB_5658EE1F539B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intravaginal live attenuated Salmonella increase local antitumor vaccine-specific CD8(+) T cells.
Journal
Oncoimmunology
Author(s)
Decrausaz L., Pythoud C., Domingos-Pereira S., Derré L., Jichlinski P., Nardelli-Haefliger D.
ISSN
2162-4011 (Print)
Publication state
Published
Issued date
2013
Volume
2
Number
1
Pages
e22944
Language
english
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish. PDF type: Brief report
Abstract
We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8(+) T cells in the genital mucosa of mice, without affecting E7-specific systemic responses. Here, we show that the instillation of live attenuated Salmonella enterica serovar Typhimurium similarly, though more efficiently (~15- fold), increases both E7-specific and total CD8(+) T cells in the genital mucosa. Cancer immunotherapeutic strategies combining vaccination with local immunostimulation with live bacteria deserve further investigations.
Pubmed
Web of science
Create date
09/05/2013 14:59
Last modification date
20/08/2019 15:10
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