The effect of arachidonic acid on the hydroosmotic action of vasopressin in frog urinary bladder.

Détails

ID Serval
serval:BIB_53FA7A036849
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The effect of arachidonic acid on the hydroosmotic action of vasopressin in frog urinary bladder.
Périodique
Biochimica et Biophysica Acta. Molecular Cell Research
Auteur(s)
Firsov D.L., Parnova R.G.
ISSN
0167-4889
ISSN-L
0167-4889
Statut éditorial
Publié
Date de publication
1994
Peer-reviewed
Oui
Volume
1220
Numéro
3
Pages
305-309
Langue
anglais
Résumé
In experiments on frog urinary bladder it was found that 23 nM arginine-vasopressin (antidiuretic hormone, AVP), 10 min after addition, increased the content of free arachidonic acid (AA) in bladder tissue from 18.6 +/- 1.2 to 33.3 +/- 3.9 ng/mg protein. The exogenous AA (10(-8) - 10(-5) M) added to the serosal Ringer solution did not change the basal level of osmotic water flow, but significantly inhibited the hydroosmotic effect of 23 nM AVP in a dose-dependent manner. The inhibitory effect of AA was not eliminated in the presence of 1 microM indomethacin, 1 microM nordihydroguaiaretic acid, 100 microM ketoconazole, nor if the nonmetabolized analog of AA, eicosatetraynoic acid (1 microM), was used instead of AA. AA inhibited only the action of vasopressin, but had no effect on osmotic water flow induced by 2 mM cAMP + 50 microM 3-isobutyl-1-methylxanthine or 20 microM forskolin. These data suggest that AA is another phospholipid-derived messenger, which modulates the hydroosmotic action of vasopressin in frog urinary bladder at a point prior to cAMP formation.
Mots-clé
1-Methyl-3-isobutylxanthine/pharmacology, Animals, Arachidonic Acid/pharmacology, Arginine Vasopressin/pharmacology, Cyclic AMP/pharmacology, Drug Interactions, Fatty Acids, Nonesterified/metabolism, Forskolin/pharmacology, Kinetics, Rana temporaria, Urinary Bladder/drug effects, Urinary Bladder/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 13:32
Dernière modification de la notice
20/08/2019 15:09
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