Differential blood pressure response to atriopeptin III and sodium nitroprusside in conscious rats with adrenal medullectomy

Détails

ID Serval
serval:BIB_539EAA30C3B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential blood pressure response to atriopeptin III and sodium nitroprusside in conscious rats with adrenal medullectomy
Périodique
European Journal of Pharmacology
Auteur(s)
Evequoz  D., Waeber  B., Matsueda  G., Nussberger  J., Brunner  H. R.
ISSN
0014-2999 (Print)
Statut éditorial
Publié
Date de publication
12/1987
Volume
144
Numéro
2
Pages
217-21
Notes
Comparative Study
Journal Article --- Old month value: Dec 1
Résumé
This study was undertaken to test whether the presence or absence of a functioning adrenal medulla influences the blood pressure response of conscious normotensive rats to a 30 min infusion of vasodilating agents such as atriopeptin III (1 microgram/min i.v.), a synthetic atrial natriuretic peptide, and sodium nitroprusside (8 micrograms/min i.v.). Rats either had their adrenal medulla removed or were sham-operated 8-10 days before the experimental day. The blood pressure lowering effect of sodium nitroprusside, but not that of atriopeptin III, was enhanced in rats with no adrenal medulla.
Mots-clé
Adrenal Medulla/*physiology/surgery Animals Atrial Natriuretic Factor/*pharmacology Blood Pressure/*drug effects Epinephrine/blood Ferricyanides/*pharmacology Heart Rate/drug effects Male Nitroprusside/*pharmacology Norepinephrine/blood Peptide Fragments/*pharmacology Rats Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 14:08
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