Differential blood pressure response to atriopeptin III and sodium nitroprusside in conscious rats with adrenal medullectomy

Details

Serval ID
serval:BIB_539EAA30C3B6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Differential blood pressure response to atriopeptin III and sodium nitroprusside in conscious rats with adrenal medullectomy
Journal
European Journal of Pharmacology
Author(s)
Evequoz  D., Waeber  B., Matsueda  G., Nussberger  J., Brunner  H. R.
ISSN
0014-2999 (Print)
Publication state
Published
Issued date
12/1987
Volume
144
Number
2
Pages
217-21
Notes
Comparative Study
Journal Article --- Old month value: Dec 1
Abstract
This study was undertaken to test whether the presence or absence of a functioning adrenal medulla influences the blood pressure response of conscious normotensive rats to a 30 min infusion of vasodilating agents such as atriopeptin III (1 microgram/min i.v.), a synthetic atrial natriuretic peptide, and sodium nitroprusside (8 micrograms/min i.v.). Rats either had their adrenal medulla removed or were sham-operated 8-10 days before the experimental day. The blood pressure lowering effect of sodium nitroprusside, but not that of atriopeptin III, was enhanced in rats with no adrenal medulla.
Keywords
Adrenal Medulla/*physiology/surgery Animals Atrial Natriuretic Factor/*pharmacology Blood Pressure/*drug effects Epinephrine/blood Ferricyanides/*pharmacology Heart Rate/drug effects Male Nitroprusside/*pharmacology Norepinephrine/blood Peptide Fragments/*pharmacology Rats Rats, Inbred Strains
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 15:08
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