Function, occurrence and inhibition of different forms of BAFF.

Détails

Ressource 1Télécharger: 2021 Review BAFF 60mer.pdf (1447.62 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_537525B04EE5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Function, occurrence and inhibition of different forms of BAFF.
Périodique
Current opinion in immunology
Auteur⸱e⸱s
Eslami M., Schneider P.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
08/2021
Peer-reviewed
Oui
Volume
71
Pages
75-80
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
B cell activating factor (BAFF or BLyS), an important cytokine for B cell survival and humoral immune responses, is targeted in the clinic for the treatment of systemic lupus erythematosus. This review focuses on the structure, function and inhibition profiles of membrane-bound BAFF, soluble BAFF 3-mer and soluble BAFF 60-mer, all of which have distinct properties. BAFF contains a loop region not required for receptor binding but essential for receptor activation via promotion of BAFF-to-BAFF contacts. This loop region additionally allows formation of BAFF 60-mer, in which epitopes of the BAFF inhibitor belimumab are inaccessible. If 60-mer forms in humans, it is predicted to be short-lived and to act locally because adult serum contains a BAFF 60-mer dissociating activity. Cord blood contains elevated levels of BAFF, part of which displays attributes of 60-mer, suggesting a role for this form of BAFF in the development of foetal or neonate B cells.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/07/2021 10:34
Dernière modification de la notice
21/11/2022 8:27
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