Function, occurrence and inhibition of different forms of BAFF.

Details

Ressource 1Download: 2021 Review BAFF 60mer.pdf (1447.62 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_537525B04EE5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Function, occurrence and inhibition of different forms of BAFF.
Journal
Current opinion in immunology
Author(s)
Eslami M., Schneider P.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Publication state
Published
Issued date
25/06/2021
Peer-reviewed
Oui
Volume
71
Pages
75-80
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
B cell activating factor (BAFF or BLyS), an important cytokine for B cell survival and humoral immune responses, is targeted in the clinic for the treatment of systemic lupus erythematosus. This review focuses on the structure, function and inhibition profiles of membrane-bound BAFF, soluble BAFF 3-mer and soluble BAFF 60-mer, all of which have distinct properties. BAFF contains a loop region not required for receptor binding but essential for receptor activation via promotion of BAFF-to-BAFF contacts. This loop region additionally allows formation of BAFF 60-mer, in which epitopes of the BAFF inhibitor belimumab are inaccessible. If 60-mer forms in humans, it is predicted to be short-lived and to act locally because adult serum contains a BAFF 60-mer dissociating activity. Cord blood contains elevated levels of BAFF, part of which displays attributes of 60-mer, suggesting a role for this form of BAFF in the development of foetal or neonate B cells.
Pubmed
Open Access
Yes
Create date
06/07/2021 11:34
Last modification date
07/07/2021 7:09
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