Trimeric G protein-dependent frizzled signaling in Drosophila.

Détails

Ressource 1Télécharger: BIB_5013D0823B92.P001.pdf (1644.29 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_5013D0823B92
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Trimeric G protein-dependent frizzled signaling in Drosophila.
Périodique
Cell
Auteur(s)
Katanaev V.L., Ponzielli R., Sémériva M., Tomlinson A.
ISSN
0092-8674 (Print)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2005
Volume
120
Numéro
1
Pages
111-122
Langue
anglais
Résumé
Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex. However, clear evidence for the role of trimeric G protein complexes for the Fz family of receptors has hitherto been lacking. Here, we show roles for the Galpha(o) subunit (Go) in mediating the two distinct pathways transduced by Fz receptors in Drosophila: the Wnt and planar polarity pathways. Go is required for transduction of both pathways, and epistasis experiments suggest that it is an immediate transducer of Fz. While overexpression effects of the wild-type form are receptor dependent, the activated form (Go-GTP) can signal when the receptor is removed. Thus, Go is likely part of a trimeric G protein complex that directly transduces Fz signals from the membrane to downstream components.
Mots-clé
Animals, Cell Polarity/genetics, Cell Polarity/physiology, Drosophila, Drosophila Proteins/metabolism, Frizzled Receptors, GTP-Binding Protein alpha Subunits, Gi-Go/genetics, GTP-Binding Protein alpha Subunits, Gi-Go/physiology, Green Fluorescent Proteins/genetics, Intercellular Signaling Peptides and Proteins/metabolism, Membrane Proteins/metabolism, Phenotype, Proto-Oncogene Proteins/metabolism, Receptors, G-Protein-Coupled, Signal Transduction, Wing/growth & development, Wing/metabolism, Wnt Proteins, Wnt1 Protein
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/12/2011 17:15
Dernière modification de la notice
20/08/2019 15:06
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