Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa.

Détails

ID Serval
serval:BIB_4EE6E7C0FD33
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa.
Périodique
Current opinion in microbiology
Auteur(s)
Valentini M., Gonzalez D., Mavridou D.A., Filloux A.
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Statut éditorial
Publié
Date de publication
02/2018
Peer-reviewed
Oui
Volume
41
Pages
15-20
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Pseudomonas aeruginosa acute and chronic infections are of great concern to human health, especially in hospital settings. It is currently assumed that P. aeruginosa has two antagonistic pathogenic strategies that parallel two different lifestyles; free-living cells are predominantly cytotoxic and induce an acute inflammatory reaction, while biofilm-forming communities cause refractory chronic infections. Recent findings suggest that the planktonic-to-sessile transition is a complex, reversible and overall dynamic differentiation process. Here, we examine how the Gac/Rsm regulatory cascade, a key player in this lifestyle switch, endows P. aeruginosa with both a permissive lifecycle in nature and flexible virulence strategy during infection.

Pubmed
Web of science
Création de la notice
30/04/2018 17:08
Dernière modification de la notice
21/08/2019 5:18
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