Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa.

Details

Serval ID
serval:BIB_4EE6E7C0FD33
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa.
Journal
Current opinion in microbiology
Author(s)
Valentini M., Gonzalez D., Mavridou D.A., Filloux A.
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
41
Pages
15-20
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Pseudomonas aeruginosa acute and chronic infections are of great concern to human health, especially in hospital settings. It is currently assumed that P. aeruginosa has two antagonistic pathogenic strategies that parallel two different lifestyles; free-living cells are predominantly cytotoxic and induce an acute inflammatory reaction, while biofilm-forming communities cause refractory chronic infections. Recent findings suggest that the planktonic-to-sessile transition is a complex, reversible and overall dynamic differentiation process. Here, we examine how the Gac/Rsm regulatory cascade, a key player in this lifestyle switch, endows P. aeruginosa with both a permissive lifecycle in nature and flexible virulence strategy during infection.

Pubmed
Web of science
Create date
30/04/2018 17:08
Last modification date
21/08/2019 5:18
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