Epithelial sodium channel: a ligand-gated channel?

Détails

ID Serval
serval:BIB_4B9DA916DAF2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Epithelial sodium channel: a ligand-gated channel?
Périodique
Nephron. Physiology
Auteur(s)
Horisberger  J. D., Chraibi  A.
ISSN
1660-2137 (Electronic)
Statut éditorial
Publié
Date de publication
2004
Volume
96
Numéro
2
Pages
p37-41
Notes
Journal Article
Review
Résumé
The epithelial sodium channel (ENaC) is a key component of the transepithelial Na+ transport. In epithelia, it is responsible for the maintenance of Na+ balance (which in turn controls extracellular fluid volume and arterial blood pressure) and the regulation of airway surface fluid. While the regulation of channel synthesis and surface density have been well described, the control of channel opening is still poorly understood. The channel has a large extracellular domain of as yet unknown function; a number of extracellular factors have been shown to modulate ENaC activity, including extracellular Na+ itself (through a phenomenon called 'self-inhibition'), several other organic or inorganic cations, which seem to interfere with self-inhibition, and serine proteases. Although a direct interaction with the extracellular domain of ENaC has not yet been demonstrated for each of these modulators, the available data strongly suggest that ENaC behaves as a ligand-gated channel similar to several other members of the ENaC/degenerin family.
Mots-clé
Animals Epithelial Sodium Channel *Ion Channel Gating Ion Channels/chemistry/metabolism Ligands Models, Biological Nerve Tissue Proteins/chemistry/metabolism Protein Structure, Tertiary Serine Endopeptidases/pharmacology Sodium/pharmacology Sodium Channels/chemistry/*metabolism
Pubmed
Création de la notice
24/01/2008 13:38
Dernière modification de la notice
20/08/2019 14:59
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