Epithelial sodium channel: a ligand-gated channel?
Details
Serval ID
serval:BIB_4B9DA916DAF2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Epithelial sodium channel: a ligand-gated channel?
Journal
Nephron. Physiology
ISSN
1660-2137 (Electronic)
Publication state
Published
Issued date
2004
Volume
96
Number
2
Pages
p37-41
Notes
Journal Article
Review
Review
Abstract
The epithelial sodium channel (ENaC) is a key component of the transepithelial Na+ transport. In epithelia, it is responsible for the maintenance of Na+ balance (which in turn controls extracellular fluid volume and arterial blood pressure) and the regulation of airway surface fluid. While the regulation of channel synthesis and surface density have been well described, the control of channel opening is still poorly understood. The channel has a large extracellular domain of as yet unknown function; a number of extracellular factors have been shown to modulate ENaC activity, including extracellular Na+ itself (through a phenomenon called 'self-inhibition'), several other organic or inorganic cations, which seem to interfere with self-inhibition, and serine proteases. Although a direct interaction with the extracellular domain of ENaC has not yet been demonstrated for each of these modulators, the available data strongly suggest that ENaC behaves as a ligand-gated channel similar to several other members of the ENaC/degenerin family.
Keywords
Animals
Epithelial Sodium Channel
*Ion Channel Gating
Ion Channels/chemistry/metabolism
Ligands
Models, Biological
Nerve Tissue Proteins/chemistry/metabolism
Protein Structure, Tertiary
Serine Endopeptidases/pharmacology
Sodium/pharmacology
Sodium Channels/chemistry/*metabolism
Pubmed
Create date
24/01/2008 13:38
Last modification date
20/08/2019 14:59