Macrophage Survival Assay Using High Content Microscopy

Détails

Ressource 1Télécharger: Bio-protocol.PDF (1965.88 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_4B76DFD4ED3B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Macrophage Survival Assay Using High Content Microscopy
Périodique
Bio-protocol
Auteur(s)
Eren R.O., Fasel N.
ISSN
2331-8325
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
7
Numéro
16
Pages
e2509
Langue
anglais
Résumé
Macrophages are phagocytic innate immune cells and are the main drivers of inflammation in tissue (Medzhitov, 2008). These cells are associated with cancer together with autoimmune, autoinflammatory, infectious, neurodegenerative and metabolic diseases (Ginhoux and Jung, 2014). In this context, the role of macrophages in inflammation is well-studied, however, the impact of macrophage survival in non-infectious and infectious diseases is largely unknown. Our study showed that the activation of certain pathogen-associated receptors (PRRs) can induce macrophage survival (Eren et al., 2016). We described a molecular mechanism that demonstrated how an obligate intracellular pathogen exploits PRR-induced cell survival (Eren et al., 2016). Thus, further studies are necessary to understand the role of macrophage survival in different disease settings.
Mots-clé
Macrophage, Cell survival, High-content microscope
Open Access
Oui
Création de la notice
22/09/2017 10:06
Dernière modification de la notice
20/08/2019 13:59
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