Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla.

Détails

ID Serval
serval:BIB_4891DB037865
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla.
Périodique
Journal of Neuroscience Research
Auteur⸱e⸱s
Schaller B., Mekle R., Xin L., Kunz N., Gruetter R.
ISSN
1097-4547 (Electronic)
ISSN-L
0360-4012
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
91
Numéro
8
Pages
1076-1083
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMRGlc ) in excess of those in oxygen (CMRO2 ) during physiological stimulation, several studies have examined the fate of the extra carbon taken up by the brain, reporting a wide range of changes in brain lactate from 20% to 250%. The present study reports functional magnetic resonance spectroscopy measurements at 7 Tesla using the enhanced sensitivity to study a small cohort (n = 6). Small increases in lactate (19% ± 4%, P < 0.05) and glutamate (4% ± 1%, P < 0.001) were seen within the first 2 min of activation. With the exception of glucose (12% ± 5%, P < 0.001), no other metabolite concentration changes beyond experimental error were significantly observed. Therefore, the present study confirms that lactate and glutamate changes during physiological stimulation are small (i.e. below 20%) and shows that the increased sensitivity allows reproduction of previous results with fewer subjects. In addition, the initial rate of glutamate and lactate concentration increases implies an increase in CMRO2 that is slightly below that of CMRGlc during the first 1-2 min of activation.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/04/2013 11:52
Dernière modification de la notice
20/08/2019 13:55
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