Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis.

Détails

ID Serval
serval:BIB_46D23138B84C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis.
Périodique
Acta haematologica
Auteur(s)
Dewarrat N., Kaiser J., Baud D., Alberio L., Gavillet M.
ISSN
1421-9662 (Electronic)
ISSN-L
0001-5792
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
143
Numéro
1
Pages
69-72
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
This original report describes the management of a pregnant woman with congenital erythrocytosis (Chuvash polycythaemia) and reviews the scarce data available in the literature. Therapy consisted of low-dose aspirin and phlebotomies to maintain haematocrit <50% while monitoring iron stores to avoid severe deficiency detrimental to the foetus. Despite normal initial foetal growth, the pregnancy was complicated by preterm birth due to chorioamnionitis. The placenta showed no signs of thrombotic events. The published reports cover 13 pregnancies in 8 patients, showing 1 first-trimester miscarriage, 5 infants with intrauterine growth restriction and/or preterm birth and 1 maternal thrombotic event. These cases were managed with phlebotomies, low-dose aspirin and/or low-molecular-weight heparin, although inconsistently.
Mots-clé
Adult, Aspirin/therapeutic use, Female, Ferritins/analysis, Heparin, Low-Molecular-Weight/therapeutic use, Homozygote, Humans, Iron/administration & dosage, Polycythemia/congenital, Polycythemia/diagnosis, Polycythemia/drug therapy, Polymorphism, Single Nucleotide, Pregnancy, Premature Birth, Von Hippel-Lindau Tumor Suppressor Protein/genetics, Congenital, Erythrocytosis, Management, Polycythaemia
Pubmed
Web of science
Création de la notice
17/06/2019 17:02
Dernière modification de la notice
27/04/2020 6:20
Données d'usage