Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis.

Details

Serval ID
serval:BIB_46D23138B84C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis.
Journal
Acta haematologica
Author(s)
Dewarrat N., Kaiser J., Baud D., Alberio L., Gavillet M.
ISSN
1421-9662 (Electronic)
ISSN-L
0001-5792
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
143
Number
1
Pages
69-72
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
This original report describes the management of a pregnant woman with congenital erythrocytosis (Chuvash polycythaemia) and reviews the scarce data available in the literature. Therapy consisted of low-dose aspirin and phlebotomies to maintain haematocrit <50% while monitoring iron stores to avoid severe deficiency detrimental to the foetus. Despite normal initial foetal growth, the pregnancy was complicated by preterm birth due to chorioamnionitis. The placenta showed no signs of thrombotic events. The published reports cover 13 pregnancies in 8 patients, showing 1 first-trimester miscarriage, 5 infants with intrauterine growth restriction and/or preterm birth and 1 maternal thrombotic event. These cases were managed with phlebotomies, low-dose aspirin and/or low-molecular-weight heparin, although inconsistently.
Keywords
Adult, Aspirin/therapeutic use, Female, Ferritins/analysis, Heparin, Low-Molecular-Weight/therapeutic use, Homozygote, Humans, Iron/administration & dosage, Polycythemia/congenital, Polycythemia/diagnosis, Polycythemia/drug therapy, Polymorphism, Single Nucleotide, Pregnancy, Premature Birth, Von Hippel-Lindau Tumor Suppressor Protein/genetics, Congenital, Erythrocytosis, Management, Polycythaemia
Pubmed
Web of science
Create date
17/06/2019 17:02
Last modification date
27/04/2020 6:20
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