The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

Sideli, L.; Aas, M.; Quattrone, D.; La Barbera, D.; La Cascia, C.; Ferraro, L.; Alameda, L.; Velthorst, E.; Trotta, G.; Tripoli, G.; Schimmenti, A.; Fontana, A.; Gayer-Anderson, C.; Stilo, S.; Seminerio, F.; Sartorio, C.; Marrazzo, G.; Lasalvia, A.; Tosato, S.; Tarricone, I.; Berardi, D.; D'Andrea, G.; Arango, C.; Arrojo, M.; Bernardo, M.; Bobes, J.; Sanjuán, J.; Santos, J.L.; Menezes, P.R.; Del-Ben, C.M.; Jongsma, H.E.; Jones, P.B.; Kirkbride, J.B.; Llorca, P.M.; Tortelli, A.; Pignon, B.; de Haan, L.; Selten, J.P.; Van Os, J.; Rutten, B.P.; Bentall, R.; Di Forti, M.; Murray, R.M.; Morgan, C.; Fisher, H.L.

doi:10.1007/s00127-023-02513-0

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

Détails

Télécharger: 37335320.pdf (585.52 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0

ID Serval

serval:BIB_45848B6E0093

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

Périodique

Social psychiatry and psychiatric epidemiology

Auteur⸱e⸱s

Sideli L., Aas M., Quattrone D., La Barbera D., La Cascia C., Ferraro L., Alameda L., Velthorst E., Trotta G., Tripoli G., Schimmenti A., Fontana A., Gayer-Anderson C., Stilo S., Seminerio F., Sartorio C., Marrazzo G., Lasalvia A., Tosato S., Tarricone I., Berardi D., D'Andrea G., Arango C., Arrojo M., Bernardo M., Bobes J., Sanjuán J., Santos J.L., Menezes P.R., Del-Ben C.M., Jongsma H.E., Jones P.B., Kirkbride J.B., Llorca P.M., Tortelli A., Pignon B., de Haan L., Selten J.P., Van Os J., Rutten B.P., Bentall R., Di Forti M., Murray R.M., Morgan C., Fisher H.L.

Collaborateur⸱rice⸱s

EU-GEI WP2 Group

Contributeur⸱rice⸱s

Amoretti S., Andreu-Bernabeu Á., Baudin G., Beards S., Bonetto C., Bonora E., Cabrera B., Carracedo A., Charpeaud T., Costas J., Cristofalo D., Cuadrado P., Durán-Cutilla M., Ferchiou A., Fraguas D., Franke N., Frijda F., Garcia-Portilla P., González Peñas J., Hubbard K., Jamain S., Jiménez-López E., Leboyer M., Llorente C., López Montoya G., Lorente-Rovira E., M Díaz-Caneja C., Marcelino Loureiro C., Matteis M., Messchaart E., Moltó M.D., Mezquida G., Moreno C., Muratori R., Nacher J., Parellada M., Rapado-Castro M., Ruggeri M., Richard J.R., Rodríguez Solano J.J., Sáiz P.A., Sánchez-Gutierrez T., Sánchez E., Schürhoff F., Seri M., Shuhama R., Termorshuizen F., Tronche A.M., van Dam D., van der Ven E.

ISSN

1433-9285 (Electronic)

ISSN-L

0933-7954

Statut éditorial

Publié

Date de publication

10/2023

Peer-reviewed

Oui

Volume

Numéro

Pages

1573-1580

Langue

anglais

Notes

Publication types: Journal Article
Publication Status: ppublish

Résumé

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Mots-clé

Adult, Humans, Child, Case-Control Studies, Psychotic Disorders/genetics, Schizophrenia/epidemiology, Schizophrenia/genetics, Cognition, Child Abuse, Childhood adversity, Family history of psychosis, First episode, Polygenic risk score, Psychosis

URN

urn:nbn:ch:serval-BIB_45848B6E00934

OAI-PMH

oai:serval.unil.ch:BIB_45848B6E0093

DOI

10.1007/s00127-023-02513-0

Pubmed

37335320

Web of science

001010796100001

Open Access

Oui