The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

Sideli, L.; Aas, M.; Quattrone, D.; La Barbera, D.; La Cascia, C.; Ferraro, L.; Alameda, L.; Velthorst, E.; Trotta, G.; Tripoli, G.; Schimmenti, A.; Fontana, A.; Gayer-Anderson, C.; Stilo, S.; Seminerio, F.; Sartorio, C.; Marrazzo, G.; Lasalvia, A.; Tosato, S.; Tarricone, I.; Berardi, D.; D'Andrea, G.; Arango, C.; Arrojo, M.; Bernardo, M.; Bobes, J.; Sanjuán, J.; Santos, J.L.; Menezes, P.R.; Del-Ben, C.M.; Jongsma, H.E.; Jones, P.B.; Kirkbride, J.B.; Llorca, P.M.; Tortelli, A.; Pignon, B.; de Haan, L.; Selten, J.P.; Van Os, J.; Rutten, B.P.; Bentall, R.; Di Forti, M.; Murray, R.M.; Morgan, C.; Fisher, H.L.

doi:10.1007/s00127-023-02513-0

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

Details

Download: 37335320.pdf (585.52 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_45848B6E0093

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

Journal

Social psychiatry and psychiatric epidemiology

Author(s)

Sideli L., Aas M., Quattrone D., La Barbera D., La Cascia C., Ferraro L., Alameda L., Velthorst E., Trotta G., Tripoli G., Schimmenti A., Fontana A., Gayer-Anderson C., Stilo S., Seminerio F., Sartorio C., Marrazzo G., Lasalvia A., Tosato S., Tarricone I., Berardi D., D'Andrea G., Arango C., Arrojo M., Bernardo M., Bobes J., Sanjuán J., Santos J.L., Menezes P.R., Del-Ben C.M., Jongsma H.E., Jones P.B., Kirkbride J.B., Llorca P.M., Tortelli A., Pignon B., de Haan L., Selten J.P., Van Os J., Rutten B.P., Bentall R., Di Forti M., Murray R.M., Morgan C., Fisher H.L.

Working group(s)

EU-GEI WP2 Group

Contributor(s)

Amoretti S., Andreu-Bernabeu Á., Baudin G., Beards S., Bonetto C., Bonora E., Cabrera B., Carracedo A., Charpeaud T., Costas J., Cristofalo D., Cuadrado P., Durán-Cutilla M., Ferchiou A., Fraguas D., Franke N., Frijda F., Garcia-Portilla P., González Peñas J., Hubbard K., Jamain S., Jiménez-López E., Leboyer M., Llorente C., López Montoya G., Lorente-Rovira E., M Díaz-Caneja C., Marcelino Loureiro C., Matteis M., Messchaart E., Moltó M.D., Mezquida G., Moreno C., Muratori R., Nacher J., Parellada M., Rapado-Castro M., Ruggeri M., Richard J.R., Rodríguez Solano J.J., Sáiz P.A., Sánchez-Gutierrez T., Sánchez E., Schürhoff F., Seri M., Shuhama R., Termorshuizen F., Tronche A.M., van Dam D., van der Ven E.

ISSN

1433-9285 (Electronic)

ISSN-L

0933-7954

Publication state

Published

Issued date

10/2023

Peer-reviewed

Oui

Volume

Number

Pages

1573-1580

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Keywords

Adult, Humans, Child, Case-Control Studies, Psychotic Disorders/genetics, Schizophrenia/epidemiology, Schizophrenia/genetics, Cognition, Child Abuse, Childhood adversity, Family history of psychosis, First episode, Polygenic risk score, Psychosis

URN

urn:nbn:ch:serval-BIB_45848B6E00934

OAI-PMH

oai:serval.unil.ch:BIB_45848B6E0093

DOI

10.1007/s00127-023-02513-0

Pubmed

37335320

Web of science

001010796100001

Open Access

Yes