Compartmental modeling of the hepatic transport of taurocholate in the rat in vivo

Détails

ID Serval
serval:BIB_44CCA840B8F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Compartmental modeling of the hepatic transport of taurocholate in the rat in vivo
Périodique
American Journal of Physiology
Auteur(s)
Deroubaix  X., Coche  T., Depiereux  E., Feytmans  E.
ISSN
0002-9513 (Print)
Statut éditorial
Publié
Date de publication
08/1989
Volume
257
Numéro
2 Pt 1
Pages
G210-20
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
Compartmental analysis was used to study the hepatobiliary transport of taurocholate (TC) in the rat in vivo. The available data are the following: [14C]TC kinetics in blood and bile, weighting factors associated with these data and computed from a theoretical variability model, and TC excretion rate in bile. The lumped model that best fits the data contains five compartments: three compartments for TC distribution in blood and two compartments for the liver. It includes a compartmental representation of the laminar flow of bile in the collecting catheter. This model overestimates TC concentration in blood. A perfusion model that includes a compartment representing explicitly the sinusoidal TC concentration gradient was developed. TC concentration in blood estimated by this model is in good agreement with direct measurements, showing that the perfused model has a better descriptive capacity than the lumped model. The amounts of TC estimated in the two hepatic compartments are similar to values previously published.
Mots-clé
Animals Bile/*metabolism Biological Transport Female Kinetics Liver/*metabolism Mathematics *Models, Theoretical Perfusion Rats Rats, Inbred Strains Taurocholic Acid/blood/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 11:03
Dernière modification de la notice
20/08/2019 13:49
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