Compartmental modeling of the hepatic transport of taurocholate in the rat in vivo
Details
Serval ID
serval:BIB_44CCA840B8F8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Compartmental modeling of the hepatic transport of taurocholate in the rat in vivo
Journal
American Journal of Physiology
ISSN
0002-9513 (Print)
Publication state
Published
Issued date
08/1989
Volume
257
Number
2 Pt 1
Pages
G210-20
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Compartmental analysis was used to study the hepatobiliary transport of taurocholate (TC) in the rat in vivo. The available data are the following: [14C]TC kinetics in blood and bile, weighting factors associated with these data and computed from a theoretical variability model, and TC excretion rate in bile. The lumped model that best fits the data contains five compartments: three compartments for TC distribution in blood and two compartments for the liver. It includes a compartmental representation of the laminar flow of bile in the collecting catheter. This model overestimates TC concentration in blood. A perfusion model that includes a compartment representing explicitly the sinusoidal TC concentration gradient was developed. TC concentration in blood estimated by this model is in good agreement with direct measurements, showing that the perfused model has a better descriptive capacity than the lumped model. The amounts of TC estimated in the two hepatic compartments are similar to values previously published.
Keywords
Animals
Bile/*metabolism
Biological Transport
Female
Kinetics
Liver/*metabolism
Mathematics
*Models, Theoretical
Perfusion
Rats
Rats, Inbred Strains
Taurocholic Acid/blood/*metabolism
Pubmed
Web of science
Create date
28/01/2008 11:03
Last modification date
20/08/2019 13:49