Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_4497C4C474D8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients.
Périodique
Kidney international reports
Auteur(s)
Schwotzer N., Kanemitsu M., Kissling S., Darioli R., Benghezal M., Rezzi S., Burnier M., Pruijm M.
ISSN
2468-0249 (Electronic)
ISSN-L
2468-0249
Statut éditorial
Publié
Date de publication
12/2020
Peer-reviewed
Oui
Volume
5
Numéro
12
Pages
2160-2167
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Supplementation of water-soluble vitamins is a common practice in hemodialysis patients, but dosages are largely based on conventional hemodialysis techniques. The aim of this study was to assess the status of water-soluble vitamins in patients on hemodiafiltration (HDF), and attempt to determine optimal dose of vitamin supplements.
This monocentric study included 40 patients on thrice-weekly chronic HDF. At baseline, all patients received 2 tablets of Dialvit containing B and C vitamins after each dialysis session. Predialysis samples of B and C vitamins were measured in both blood (n = 40) and a subgroup of dialysate (n = 6) samples. A second blood sample was obtained in 24 patients 3 months after dose adjustment of the vitamin supplement.
At baseline, B-vitamin levels were high with, respectively, 0.4%, 10.0%, and 89.6% of patients in the low, normal, and high reference range. For vitamin C, most patients were in the normal range (5.0%, 82.5%, and 12.5% in low, normal, and high reference range). Three months after dose reduction, B vitamin levels decreased but stayed mostly at or above the normal range (1.4%, 25.7%, 72.9% in low, normal, and high reference range). Three patients (12.5%) developed vitamin C deficiency on low-dose substititon.
This study shows that the levels of most vitamins are above the normal range in patients on HDF receiving a classic dose of vitamin supplements, vitamin C excepted. Our study suggests that the classic dose of postdialysis vitamin B supplements may be reduced.
Mots-clé
clearance, hemodiafiltration, hemodialysis, vitamin B, vitamin C
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/12/2020 10:49
Dernière modification de la notice
30/04/2021 6:10
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