Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_4497C4C474D8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients.
Journal
Kidney international reports
Author(s)
Schwotzer N., Kanemitsu M., Kissling S., Darioli R., Benghezal M., Rezzi S., Burnier M., Pruijm M.
ISSN
2468-0249 (Electronic)
ISSN-L
2468-0249
Publication state
Published
Issued date
12/2020
Peer-reviewed
Oui
Volume
5
Number
12
Pages
2160-2167
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Supplementation of water-soluble vitamins is a common practice in hemodialysis patients, but dosages are largely based on conventional hemodialysis techniques. The aim of this study was to assess the status of water-soluble vitamins in patients on hemodiafiltration (HDF), and attempt to determine optimal dose of vitamin supplements.
This monocentric study included 40 patients on thrice-weekly chronic HDF. At baseline, all patients received 2 tablets of Dialvit containing B and C vitamins after each dialysis session. Predialysis samples of B and C vitamins were measured in both blood (n = 40) and a subgroup of dialysate (n = 6) samples. A second blood sample was obtained in 24 patients 3 months after dose adjustment of the vitamin supplement.
At baseline, B-vitamin levels were high with, respectively, 0.4%, 10.0%, and 89.6% of patients in the low, normal, and high reference range. For vitamin C, most patients were in the normal range (5.0%, 82.5%, and 12.5% in low, normal, and high reference range). Three months after dose reduction, B vitamin levels decreased but stayed mostly at or above the normal range (1.4%, 25.7%, 72.9% in low, normal, and high reference range). Three patients (12.5%) developed vitamin C deficiency on low-dose substititon.
This study shows that the levels of most vitamins are above the normal range in patients on HDF receiving a classic dose of vitamin supplements, vitamin C excepted. Our study suggests that the classic dose of postdialysis vitamin B supplements may be reduced.
Keywords
clearance, hemodiafiltration, hemodialysis, vitamin B, vitamin C
Pubmed
Web of science
Open Access
Yes
Create date
22/12/2020 11:49
Last modification date
30/04/2021 7:10
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