Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_448E1556B8F5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses.
Périodique
Human vaccines & immunotherapeutics
Auteur⸱e⸱s
Bovay A., Fuertes Marraco S.A., Speiser D.E.
ISSN
2164-554X (Electronic)
ISSN-L
2164-5515
Statut éditorial
Publié
Date de publication
03/08/2021
Peer-reviewed
Oui
Volume
17
Numéro
8
Pages
2471-2481
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
By preventing infectious diseases, vaccines contribute substantially to public health. Besides, they offer great opportunities to investigate human immune responses. This is particularly true for live-attenuated virus vaccines which cause resolving acute infections and induce robust immunity. The fact that one can precisely schedule the time-point of vaccination enables complete characterization of the immune response over time, short-term and over many years. The live-attenuated Yellow Fever virus vaccine strain YF-17D was developed in the 1930's and gave rise to the 17D-204 and 17DD vaccine sub-strains, administered to over 600 million individuals worldwide. YF vaccination causes a systemic viral infection, which induces neutralizing antibodies that last for a lifetime. It also induces a strong T cell response resembling the ones of acute infections, in contrast to most other vaccines. In spite of its use since 1937, learning how YF vaccination stimulates such strong and persistent immune responses has gained substantial knowledge only in the last decades. Here we summarize the current state of knowledge on the immune response to YF vaccination, and discuss its contribution as a human model to address complex questions on optimal immune responses.
Mots-clé
Antibodies, Viral, Humans, Immunity, Vaccination, Vaccines, Attenuated, Yellow Fever/prevention & control, Yellow Fever Vaccine, Yellow fever virus, B cells, Immune response, T cells, Yellow Fever vaccination
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/05/2021 8:19
Dernière modification de la notice
12/01/2022 7:09
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