Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses.

Details

Serval ID
serval:BIB_448E1556B8F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses.
Journal
Human vaccines & immunotherapeutics
Author(s)
Bovay A., Fuertes Marraco S.A., Speiser D.E.
ISSN
2164-554X (Electronic)
ISSN-L
2164-5515
Publication state
In Press
Peer-reviewed
Oui
Pages
1-11
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
By preventing infectious diseases, vaccines contribute substantially to public health. Besides, they offer great opportunities to investigate human immune responses. This is particularly true for live-attenuated virus vaccines which cause resolving acute infections and induce robust immunity. The fact that one can precisely schedule the time-point of vaccination enables complete characterization of the immune response over time, short-term and over many years. The live-attenuated Yellow Fever virus vaccine strain YF-17D was developed in the 1930's and gave rise to the 17D-204 and 17DD vaccine sub-strains, administered to over 600 million individuals worldwide. YF vaccination causes a systemic viral infection, which induces neutralizing antibodies that last for a lifetime. It also induces a strong T cell response resembling the ones of acute infections, in contrast to most other vaccines. In spite of its use since 1937, learning how YF vaccination stimulates such strong and persistent immune responses has gained substantial knowledge only in the last decades. Here we summarize the current state of knowledge on the immune response to YF vaccination, and discuss its contribution as a human model to address complex questions on optimal immune responses.
Keywords
B cells, Immune response, T cells, Yellow Fever vaccination
Pubmed
Web of science
Open Access
Yes
Create date
11/05/2021 9:19
Last modification date
29/05/2021 6:31
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