MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment
Détails
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Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_4344DC6AC930
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment
Périodique
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
Statut éditorial
Publié
Date de publication
02/2004
Volume
189
Numéro
4
Pages
583-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Résumé
Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.
Mots-clé
Acquired Immunodeficiency Syndrome/*genetics/physiopathology
Base Sequence
CD4-Positive T-Lymphocytes/immunology
Cohort Studies
DNA Primers
Disease Progression
Genes, MDR/*genetics
Genotype
HIV Infections/*genetics/physiopathology
Hiv-1
Humans
*Polymorphism, Genetic
Variation (Genetics)
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
25/08/2023 23:10