MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment

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Serval ID
serval:BIB_4344DC6AC930
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment
Journal
Journal of Infectious Diseases
Author(s)
Bleiber  G., May  M., Suarez  C., Martinez  R., Marzolini  C., Egger  M., Telenti  A.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
02/2004
Volume
189
Number
4
Pages
583-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Abstract
Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.
Keywords
Acquired Immunodeficiency Syndrome/*genetics/physiopathology Base Sequence CD4-Positive T-Lymphocytes/immunology Cohort Studies DNA Primers Disease Progression Genes, MDR/*genetics Genotype HIV Infections/*genetics/physiopathology Hiv-1 Humans *Polymorphism, Genetic Variation (Genetics)
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:46
Last modification date
25/09/2019 7:09
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