The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.
Détails
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_4275AE8CF8AF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.
Périodique
Radiotherapy and oncology
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Statut éditorial
Publié
Date de publication
09/2023
Peer-reviewed
Oui
Volume
186
Pages
109767
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
Mots-clé
Mice, Animals, Neuronal Plasticity/physiology, Long-Term Potentiation/physiology, Hippocampus/physiology, Synaptic Transmission/physiology, FLASH radiotherapy, Long-term potentiation, Standard-of care fractionation
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/07/2023 16:32
Dernière modification de la notice
10/02/2024 8:20
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