The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_4275AE8CF8AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.
Journal
Radiotherapy and oncology
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
Published
Issued date
09/2023
Peer-reviewed
Oui
Volume
186
Pages
109767
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
Keywords
Mice, Animals, Neuronal Plasticity/physiology, Long-Term Potentiation/physiology, Hippocampus/physiology, Synaptic Transmission/physiology, FLASH radiotherapy, Long-term potentiation, Standard-of care fractionation
Pubmed
Web of science
Open Access
Yes
Create date
03/07/2023 15:32
Last modification date
10/02/2024 7:20
Usage data
