Enzymatic activity, ultrastructure and function in ganglia infected with a neurotropic virus.

Détails

ID Serval
serval:BIB_423D3C7C075B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Enzymatic activity, ultrastructure and function in ganglia infected with a neurotropic virus.
Périodique
Progress in Brain Research
Auteur(s)
Dolivo M., Honegger P., George C., Kiraly M., Bommeli W.
ISSN
0079-6123 (Print)
ISSN-L
0079-6123
Statut éditorial
Publié
Date de publication
1979
Volume
51
Pages
51-57
Langue
anglais
Résumé
This chapter attempts to answer the questions, how do the viruses reach the neurons, what are the alterations that they impose on the neuronal machinery, and what are the consequences of these alterations on the function of the infected neurons? The virus used for this research was the pseudorabies. Pseudorabies virus is transported from the eye to the superior cervical ganglion by retrograde axonal flow. In the sympathetic neurons, the virus induces an increased protein synthesis and tyrosine 3-monooxygenase activity, a transsynaptic increased activity of the cholineacetyltransferase and a great rise in the acetylcholine content. The virus also causes an abnormal spontaneous electrophysiological activity, which also seems to be of presynaptic origin, despite the fact that the virus never crossed the synaptic cleft.
Mots-clé
Acetylcholine/metabolism, Animals, Choline O-Acetyltransferase/metabolism, Ganglia/microbiology, Ganglia/ultrastructure, Herpesvirus 1, Suid, Neuroglia/metabolism, Neuroglia/microbiology, Rats
Pubmed
Création de la notice
24/01/2008 14:11
Dernière modification de la notice
20/08/2019 14:44
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