Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury.

Détails

ID Serval
serval:BIB_41B91F37631E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury.
Périodique
The Journal of cell biology
Auteur(s)
Pot C., Simonen M., Weinmann O., Schnell L., Christ F., Stoeckle S., Berger P., Rülicke T., Suter U., Schwab M.E.
ISSN
0021-9525 (Print)
ISSN-L
0021-9525
Statut éditorial
Publié
Date de publication
14/10/2002
Peer-reviewed
Oui
Volume
159
Numéro
1
Pages
29-35
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Injured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired after a sciatic nerve crush. Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration.
Mots-clé
Animals, Axons/physiology, GAP-43 Protein/metabolism, Gene Expression Regulation, Growth Inhibitors/genetics, Growth Inhibitors/metabolism, HeLa Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myelin Proteins/genetics, Myelin Proteins/metabolism, Nerve Crush, Nerve Regeneration/physiology, Nogo Proteins, Rats, Schwann Cells/metabolism, Sciatic Nerve/injuries, Sciatic Nerve/physiology, Sciatic Nerve/ultrastructure, Transgenes
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/08/2018 17:20
Dernière modification de la notice
20/08/2019 14:42
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