Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury.

Details

Serval ID
serval:BIB_41B91F37631E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury.
Journal
The Journal of cell biology
Author(s)
Pot C., Simonen M., Weinmann O., Schnell L., Christ F., Stoeckle S., Berger P., Rülicke T., Suter U., Schwab M.E.
ISSN
0021-9525 (Print)
ISSN-L
0021-9525
Publication state
Published
Issued date
14/10/2002
Peer-reviewed
Oui
Volume
159
Number
1
Pages
29-35
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Injured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired after a sciatic nerve crush. Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration.
Keywords
Animals, Axons/physiology, GAP-43 Protein/metabolism, Gene Expression Regulation, Growth Inhibitors/genetics, Growth Inhibitors/metabolism, HeLa Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myelin Proteins/genetics, Myelin Proteins/metabolism, Nerve Crush, Nerve Regeneration/physiology, Nogo Proteins, Rats, Schwann Cells/metabolism, Sciatic Nerve/injuries, Sciatic Nerve/physiology, Sciatic Nerve/ultrastructure, Transgenes
Pubmed
Web of science
Open Access
Yes
Create date
21/08/2018 16:20
Last modification date
20/08/2019 13:42
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