X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
Détails
ID Serval
serval:BIB_402C7A2329DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
Périodique
Radiotherapy and oncology
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Statut éditorial
Publié
Date de publication
12/2018
Peer-reviewed
Oui
Volume
129
Numéro
3
Pages
582-588
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
Mots-clé
Animals, Brain Injuries/prevention & control, Cranial Irradiation/adverse effects, Cranial Irradiation/methods, Female, Hippocampus/radiation effects, Memory/radiation effects, Mice, Mice, Inbred C57BL, Radiation Injuries, Experimental/prevention & control, Synchrotrons, X-Rays, Cognitive impairment, Radiation-induced brain injury, Synchrotron radiation, Ultra-high dose-rate X-ray radiation
Pubmed
Web of science
Création de la notice
10/09/2018 14:32
Dernière modification de la notice
28/09/2019 6:08
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