X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
Details
Serval ID
serval:BIB_402C7A2329DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
Journal
Radiotherapy and oncology
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
129
Number
3
Pages
582-588
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
Keywords
Animals, Brain Injuries/prevention & control, Cranial Irradiation/adverse effects, Cranial Irradiation/methods, Female, Hippocampus/radiation effects, Memory/radiation effects, Mice, Mice, Inbred C57BL, Radiation Injuries, Experimental/prevention & control, Synchrotrons, X-Rays, Cognitive impairment, Radiation-induced brain injury, Synchrotron radiation, Ultra-high dose-rate X-ray radiation
Pubmed
Web of science
Create date
10/09/2018 13:32
Last modification date
28/09/2019 5:08
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