Recent advances and hurdles in melanoma immunotherapy.

Détails

ID Serval
serval:BIB_3FF2501DE921
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Recent advances and hurdles in melanoma immunotherapy.
Périodique
Pigment cell & melanoma research
Auteur⸱e⸱s
Jandus C., Speiser D., Romero P.
ISSN
1755-148X[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
22
Numéro
6
Pages
711-723
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Worldwide incidence of malignant melanoma has been constantly increasing during the last years. Surgical excision is effective when primary tumours are thin. At later disease stages patients often succumb, due to failure of metastasis control. Therefore, great efforts have been made to develop improved strategies to treat metastatic melanoma patients. In the search for novel treatments during the last two decades, immunotherapy has occupied a prominent place. Numerous early phase immunotherapy clinical trials, generally involving small numbers of patients each time, have been reported: significant tumour-specific immune responses could often be measured in patients upon treatments. However, clinical responses remain at a dismal low rate. In some anecdotal cases, objective clinical benefit was more frequently observed among immune responders than immune non-responders. This clearly calls for a better understanding of protective immunity against tumours as well as the cross talk taking place between tumours and the immune system. Here we discuss advances and limitations of specific immunotherapy against human melanoma in the light of the literature from the last 5 yr.
Mots-clé
T-cells , tumor immunity , cancer vaccines , adoptive cell transfer therapy , immune monitoring , adjuvants
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/01/2010 16:26
Dernière modification de la notice
20/08/2019 14:37
Données d'usage