Recent advances and hurdles in melanoma immunotherapy.

Details

Serval ID
serval:BIB_3FF2501DE921
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recent advances and hurdles in melanoma immunotherapy.
Journal
Pigment cell & melanoma research
Author(s)
Jandus C., Speiser D., Romero P.
ISSN
1755-148X[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
22
Number
6
Pages
711-723
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Worldwide incidence of malignant melanoma has been constantly increasing during the last years. Surgical excision is effective when primary tumours are thin. At later disease stages patients often succumb, due to failure of metastasis control. Therefore, great efforts have been made to develop improved strategies to treat metastatic melanoma patients. In the search for novel treatments during the last two decades, immunotherapy has occupied a prominent place. Numerous early phase immunotherapy clinical trials, generally involving small numbers of patients each time, have been reported: significant tumour-specific immune responses could often be measured in patients upon treatments. However, clinical responses remain at a dismal low rate. In some anecdotal cases, objective clinical benefit was more frequently observed among immune responders than immune non-responders. This clearly calls for a better understanding of protective immunity against tumours as well as the cross talk taking place between tumours and the immune system. Here we discuss advances and limitations of specific immunotherapy against human melanoma in the light of the literature from the last 5 yr.
Keywords
T-cells , tumor immunity , cancer vaccines , adoptive cell transfer therapy , immune monitoring , adjuvants
Pubmed
Web of science
Open Access
Yes
Create date
15/01/2010 15:26
Last modification date
20/08/2019 13:37
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