The MHC Motif Atlas: a database of MHC binding specificities and ligands.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_3F10404EDD7E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The MHC Motif Atlas: a database of MHC binding specificities and ligands.
Périodique
Nucleic acids research
Auteur⸱e⸱s
Tadros D.M., Eggenschwiler S., Racle J., Gfeller D.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
06/01/2023
Peer-reviewed
Oui
Volume
51
Numéro
D1
Pages
D428-D437
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. This process is fundamental for eliciting T-cell recognition of infected or malignant cells. Epitopes displayed on MHC molecules further provide therapeutic targets for personalized cancer vaccines or adoptive T-cell therapy. To help visualizing, analyzing and comparing the different binding specificities of MHC molecules, we developed the MHC Motif Atlas (http://mhcmotifatlas.org/). This database contains information about thousands of class I and class II MHC molecules, including binding motifs, peptide length distributions, motifs of phosphorylated ligands, multiple specificities or links to X-ray crystallography structures. The database further enables users to download curated datasets of MHC ligands. By combining intuitive visualization of the main binding properties of MHC molecules together with access to more than a million ligands, the MHC Motif Atlas provides a central resource to analyze and interpret the binding specificities of MHC molecules.
Mots-clé
Epitopes, T-Lymphocyte, Histocompatibility Antigens Class II, Ligands, Peptides/chemistry, Protein Binding, Major Histocompatibility Complex, Atlases as Topic
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/11/2022 9:02
Dernière modification de la notice
09/12/2023 7:02
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