One person with two DNA profiles: a(nother) case of mosaicism or chimerism.

Détails

Ressource 1Télécharger: serval:BIB_3F08F309B447.P001 (86.06 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_3F08F309B447
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
One person with two DNA profiles: a(nother) case of mosaicism or chimerism.
Périodique
International journal of legal medicine
Auteur(s)
Castella V., Lesta Maria del Mar, Mangin P.
ISSN
1437-1596[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
123
Numéro
5
Pages
427-30
Langue
anglais
Résumé
Nuclear DNA markers, such as short tandem repeats (STR), are widely used for crime investigation and paternity testing. STR were used to determine whether a piece of tissue regurgitated by a dog was part of the penis of a dead, emasculated, man. Unexpectedly, when analyzing the recovered material and a blood sample from the deceased, five out of the 18 loci differed. According to the results, one could have concluded that these samples originated from two different persons. However, taking into account contextual information and data from complementary genetic analyses, the most likely hypothesis was that the deceased was a genetic mosaic or a chimera. Within a forensic genetic context, such genetic peculiarities may prevent associating the perpetrator of an offense with a stain left at a crime scene or lead to false paternity exclusions. Fast recognition of mosaics or chimeras, adapted sampling scheme, as well as careful interpretation of the data should allow avoiding such pitfalls.
Mots-clé
Aged, 80 and over, Animals, Chimerism, DNA/genetics, DNA Fingerprinting, Dogs, Forensic Genetics, Humans, Male, Mosaicism, Penis/injuries, Penis/pathology, Polymerase Chain Reaction, Tandem Repeat Sequences
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/02/2010 11:55
Dernière modification de la notice
01/10/2019 6:17
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