One person with two DNA profiles: a(nother) case of mosaicism or chimerism.

Details

Ressource 1Download: serval:BIB_3F08F309B447.P001 (86.06 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_3F08F309B447
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
One person with two DNA profiles: a(nother) case of mosaicism or chimerism.
Journal
International journal of legal medicine
Author(s)
Castella V., Lesta Maria del Mar, Mangin P.
ISSN
1437-1596[electronic]
Publication state
Published
Issued date
2009
Volume
123
Number
5
Pages
427-30
Language
english
Abstract
Nuclear DNA markers, such as short tandem repeats (STR), are widely used for crime investigation and paternity testing. STR were used to determine whether a piece of tissue regurgitated by a dog was part of the penis of a dead, emasculated, man. Unexpectedly, when analyzing the recovered material and a blood sample from the deceased, five out of the 18 loci differed. According to the results, one could have concluded that these samples originated from two different persons. However, taking into account contextual information and data from complementary genetic analyses, the most likely hypothesis was that the deceased was a genetic mosaic or a chimera. Within a forensic genetic context, such genetic peculiarities may prevent associating the perpetrator of an offense with a stain left at a crime scene or lead to false paternity exclusions. Fast recognition of mosaics or chimeras, adapted sampling scheme, as well as careful interpretation of the data should allow avoiding such pitfalls.
Keywords
Aged, 80 and over, Animals, Chimerism, DNA/genetics, DNA Fingerprinting, Dogs, Forensic Genetics, Humans, Male, Mosaicism, Penis/injuries, Penis/pathology, Polymerase Chain Reaction, Tandem Repeat Sequences
Pubmed
Web of science
Open Access
Yes
Create date
04/02/2010 11:55
Last modification date
01/10/2019 6:17
Usage data