Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla.

Détails

ID Serval
serval:BIB_3EAEF88E8B9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla.
Périodique
Developmental Neuroscience
Auteur(s)
Gruetter R., Seaquist E.R., Kim S., Ugurbil K.
ISSN
0378-5866 (Print)
ISSN-L
0378-5866
Statut éditorial
Publié
Date de publication
1998
Volume
20
Numéro
4-5
Pages
380-388
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
Using optimized administration of 13C-labeled glucose, the time course of the specific activity of glucose was measured directly by in vivo 13C-NMR in the human brain at 4 Tesla. Subsequent label incorporation was measured at the C2, C3 and C4 positions of both glutamate and the well-resolved C2, C3 and C4 resonances of glutamine and at the C2 and C3 positions of aspartate. GABA was clearly observed for the first time in vivo, suggesting a substantial GABA turnover in the normal human visual cortex. Likewise, lactate C3 labeled with an estimated active pool size on the order of 0.5 mM. A model of cerebral glutamate metabolism is proposed which predicts that glutamatergic action ('neurotransmission'), pyruvate carboxylase flux, TCA cycle activity, glucose consumption and exchange across the mitochondrial membrane can be assessed simultaneously in the human brain.
Mots-clé
Aspartic Acid/analogs & derivatives, Aspartic Acid/metabolism, Blood Glucose/metabolism, Brain/metabolism, Carbon Isotopes, Glucose/metabolism, Glutamic Acid/metabolism, Glutamine/metabolism, Humans, Lactic Acid/metabolism, Magnetic Resonance Spectroscopy, Magnetics, Models, Biological, Visual Cortex/metabolism, gamma-Aminobutyric Acid/metabolism
Pubmed
Web of science
Création de la notice
04/08/2010 15:28
Dernière modification de la notice
20/08/2019 13:35
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