Functional harmonics reveal multi-dimensional basis functions underlying cortical organization.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_3DB476CD4FC5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Functional harmonics reveal multi-dimensional basis functions underlying cortical organization.
Périodique
Cell reports
Auteur⸱e⸱s
Glomb K., Kringelbach M.L., Deco G., Hagmann P., Pearson J., Atasoy S.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
24/08/2021
Peer-reviewed
Oui
Volume
36
Numéro
8
Pages
109554
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The human brain consists of specialized areas that flexibly interact to form a multitude of functional networks. Complementary to this notion of modular organization, brain function has been shown to vary along a smooth continuum across the whole cortex. We demonstrate a mathematical framework that accounts for both of these perspectives: harmonic modes. We calculate the harmonic modes of the brain's functional connectivity graph, called "functional harmonics," revealing a multi-dimensional, frequency-ordered set of basis functions. Functional harmonics link characteristics of cortical organization across several spatial scales, capturing aspects of intra-areal organizational features (retinotopy, somatotopy), delineating brain areas, and explaining macroscopic functional networks as well as global cortical gradients. Furthermore, we show how the activity patterns elicited by seven different tasks are reconstructed from a very small subset of functional harmonics. Our results suggest that the principle of harmonicity, ubiquitous in nature, also underlies functional cortical organization in the human brain.
Mots-clé
Cerebral Cortex/physiology, Connectome, Female, Humans, Male, Models, Neurological, brain networks, fMRI, functional connectivity, harmonic modes, human cortex
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / Programmes / CRSII5_170873
Création de la notice
03/09/2021 16:57
Dernière modification de la notice
25/01/2024 7:34
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