Functional harmonics reveal multi-dimensional basis functions underlying cortical organization.

Details

Serval ID
serval:BIB_3DB476CD4FC5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Functional harmonics reveal multi-dimensional basis functions underlying cortical organization.
Journal
Cell reports
Author(s)
Glomb K., Kringelbach M.L., Deco G., Hagmann P., Pearson J., Atasoy S.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
24/08/2021
Peer-reviewed
Oui
Volume
36
Number
8
Pages
109554
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The human brain consists of specialized areas that flexibly interact to form a multitude of functional networks. Complementary to this notion of modular organization, brain function has been shown to vary along a smooth continuum across the whole cortex. We demonstrate a mathematical framework that accounts for both of these perspectives: harmonic modes. We calculate the harmonic modes of the brain's functional connectivity graph, called "functional harmonics," revealing a multi-dimensional, frequency-ordered set of basis functions. Functional harmonics link characteristics of cortical organization across several spatial scales, capturing aspects of intra-areal organizational features (retinotopy, somatotopy), delineating brain areas, and explaining macroscopic functional networks as well as global cortical gradients. Furthermore, we show how the activity patterns elicited by seven different tasks are reconstructed from a very small subset of functional harmonics. Our results suggest that the principle of harmonicity, ubiquitous in nature, also underlies functional cortical organization in the human brain.
Keywords
Cerebral Cortex/physiology, Connectome, Female, Humans, Male, Models, Neurological, brain networks, fMRI, functional connectivity, harmonic modes, human cortex
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Programmes / CRSII5_170873
Create date
03/09/2021 17:57
Last modification date
01/03/2022 7:39
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